Medical Portal

Researchers have found a new key to a solution of why wide-spread medicine against AIDS causes the certain side-effects, as for example strange depot fat. In scientists’ opinion, comparison of side action from protease inhibitor (the dangerous components contained in a mix of medicines against HIV) and genetic predisposition, bringing in early ageing, can explain the reason of frequent exhaustions of depot fat and other consequences.

Protease inhibits can cause metabolism problems, namely unhealthy accumulation of cholesterol in blood, high blood pressure and the increased risk of diabetes. They also cause such disease as lipodystrophy - strange redistribution of corporal fat owing to what patients have hollow cheeks and weakened extremities, and also so-called «buffaloes hump» - accumulation of fat on a back part of a neck.

Now researchers want to see, whether their theory concerning the version about protease inhibits which do not block ZMPSTE24 and can cause less side-effects in a HIV+ people is true. Researches are published in the Proceedings of the National Academy of Sciences.