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Scientists from the Medical center Beth Israel Deaconess have revealed the part of a brain responsible for rise of body temperature. Selective blocking of this center located in hypothalamus, can become a basis for creation of specific antifebriles, informs Nature Neuroscience.
Earlier scientists know, that the inflammation is accompanied by secretion of biologically active substance - prostaglandin Е2. This compound influences hypothalamus - part of a brain responsible for vegetative regulation of body temperature, appetite, water balance, sexual activity, a vascular tone, etc.
Clifford Saper and his colleagues have aimed to establish the specificsite of hypothalamus, responsible for rise of body temperature. Experiments were run on mice.
According to the scientist, finally they have managed to find “pin-headâ€? part of the brain, and “switching off” its EP3-receptors blocked development of the fever. The area playing a key role in rise of body temperature appeared the medial preoptic nucleus located in a median zone of hypothalamus.
«We assume, that in a human brain all happens precisely the same way», - declared Saper.
The antifebriles used now (for example, aspirin), influence all prostaglandin receptors in an organism – that is why there are a lot of side-effects. The new data allow to begin development of more safe preparations influencing specific receptors, the summarized scientist.